Laboratory for Biomedical Research

Research activity of the Laboratory for Biomedical Research is based on the study of molecular mechanisms of pathophysiological changes in pregnancy (pre-eclampsia, hypothyroidism and thrombophilia) and the physiological mechanisms of redox homeostasis, cell proliferation and migration, as well as on the investigation of biological activities of synthesised and natural active substances.

Mission: Through scientific research and education, combined with the continuous professional development of researchers, methods and research techniques, the Laboratory contributes to the advancement of existing knowledge and to the development of new insights in the fields of human physiology and cell biology.

Vision: The Laboratory aims to develop into a Centre of Excellence in biomedical interdisciplinary and transdisciplinary research, to establish international scientific cooperation, and to contribute to the integration of the State University of Novi Pazar into the European Research Area.

Laboratory Members

Prof. Dr Nataša Đorđević
1. Prof. Dr Nataša Đorđević
Principal Investigator
natasadj@np.ac.rs
Prof. Dr Zana Dolićanin
2. Prof. Dr Zana Dolićanin
zdolicanin@np.ac.rs
Nejla Župić
3. Nejla Župić, Teaching Assistant
nzupic@np.ac.rs

Associate Members

  • Sajda Crnovršanin, MSc Biology student
  • Tanja Novaković, PhD Biology student
  • Maida Leković, PhD Biology student
  • Neresa Dreković, PhD Biology student
  • Nihat Granica, PhD Biology student
  • Emina Stupljanin, MSc Biology student
  • Teida Mekić, MSc Biology student
  • Cenisa Šahović, MSc Biology student

Research Resources

Research Equipment — PDF
Laboratory equipment 1
Laboratory equipment 2
Laboratory equipment 3

Cell Lines

  1. HCT-116: human colorectal carcinoma cell lines (ATCC)
  2. MRC-5: human lung fibroblast cell lines (ATCC)
  3. HTR-8/SVneo: human extravillous trophoblast cell lines (ATCC)

Research Projects

Projects of the Ministry of Education, Science and Technological Development of the Republic of Serbia 2011–2019:

  • "Molecular physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress", no. 173041.
  • "Aetiology, diagnosis, prevention and therapy of endemic nephropathy and associated urothelial tumours", no. 175092.

Collaboration with Research Institutions

  • Faculty of Medical Sciences, University of Kragujevac.
  • University Clinical Centre "Kragujevac".
  • Institute of Biology and Ecology, Faculty of Science, University of Kragujevac.
  • Institute of Chemistry, Faculty of Science, University of Kragujevac.
  • Department of Physiology, Institute of Biological Research "Siniša Stanković", University of Belgrade.
  • Laboratory for Bioinformatics and Applied Biology, Institute of Information Technologies, University of Kragujevac.
  • Faculty of Agriculture, University of Belgrade.
  • Laboratory for Cell Biology, Institut Curie, Paris, France.

Achievements

Doctoral Dissertation

Master's Theses

Scientific Papers

  1. Djordjevic ZN, Novakovic RT, Dolicanin CZ, Jovic DN, Babic MG. Maternal thrombophilia disrupts fetal redox homeostasis. Reproductive Sciences. 2025. DOI
  2. Avdić A, Đorđević N, Marovac U, Memić L, Dolićanin Z, Babić G. Predicting thrombophilia using neural networks and decision trees. Scientific Publications of the State University of Novi Pazar Series A. 2023;15(2):97–108.
  3. Lekovic MH, Drekovic NE, Granica NDz, Mahmutovic EH, Djordjevic NZ. Extremely low-frequency electromagnetic field induces a change in proliferative capacity and redox homeostasis of human lung fibroblast cell line MRC-5. Environmental Science and Pollution Research. 2020;27:39466–39473. DOI
  4. Novakovic RT, Dolicanin CZ, Babic MG, Djordjevic ZN. The maternal leucocytes in thrombophilia and hypothyroidism and their influence on fetal cells. Ser J Exp Clin Res. 2020;21(3):217–223. PDF
  5. Stikic IR, Milincic DD, et al. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. Cereal Chemistry. 2020;97:626–633. DOI
  6. Veljkovic PB, Djordjevic ZN, et al. Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.). Not Bot Horti Agrobo. 2019;47(2):359–367. DOI
  7. Novakovic RT, Dolicanin CZ, Djordjevic ZN. Oxidative stress biomarkers in amniotic fluid of pregnant women with hypothyroidism. Journal of Maternal-Fetal and Neonatal Medicine. 2019;32:1105–1110. DOI
  8. Radenković N, Kostić DM, Đorđević ZN, et al. Synthesis of new Pt(II) complex bearing organoselenium ligands and evaluation of cytotoxic activity of some structurally related Pd(II) complexes. Macedonian Journal of Chemistry and Chemical Engineering. 2020;39:59–64. DOI
  9. Novakovic RT, Dolicanin CZ, Djordjevic ZN. Effects of maternal subclinical hypothyroidism on amniotic fluid cells oxidative status. Reproductive Toxicology. 2018;78:97–101. DOI

Conference Presentations

  1. Zupic HN, Dolicanin CZ, Djordjevic ZN. Neuropeptide Y disrupts redox balance in human extravillous trophoblasts. 5th International congress of Serbian society for mitochondrial and free radical physiology. Belgrade, Serbia. September 27–29, 2024. Abstract Book p. 58.
  2. Marovac AU, Memić ML, Avdić RA, Djordjević ZN, Dolicanin CZ, Babić NG. Selecting critical features for biomedical data classification. 2nd International Conference on Chemo and Bioinformatics, Kragujevac. September 28–29, 2023. Book of proceedings p. 136–139.
  3. Avdić RA, Djordjević ZN, Marovac AU, Memić ML, Dolicanin CZ, Babić NG. Thrombophilia prediction using machine learning algorithms. 2nd International Conference on Chemo and Bioinformatics, Kragujevac. September 28–29, 2023. Book of proceedings p. 140–143.
  4. Đorđević N, Babić G, Ognjanović B, Dolićanin Z. Effects of estradiol on S-nitrosoglutathione formation in erythrocytes of pregnant women with pre-eclampsia. I Conference of the Serbian Biological Society "Stevan Jakovljević", Kragujevac. September 20–22, 2023. Abstract Book p. 95.
  5. Župić N, Dolićanin Z, Veljković B, Đorđević N. Anticancer activity of Ornithogalum umbellatum in colorectal carcinoma cells mediated by changes in the redox status of the cell. I Conference of the Serbian Biological Society "Stevan Jakovljević", Kragujevac. September 20–22, 2023. Abstract Book p. 100.
  6. Marovac U, Avdić A, Đorđević N, Babić G, Memić L. Feature extraction for biomedical data classification. ELICSIR Project Symposium, Niš. January 25–27, 2023. Book of Abstracts, p. 56.
  7. Đorđević N, Babić N, Marković S, Jakovljević V, Veljković B. The effects of estradiol therapy on oxidative stress markers in erythrocytes and blood pressure in preeclampsia. IV symposium of biologist and ecologist of Republic of Srpska – SBERS2020. November 12–14, 2020. Abstract Book p. 64.
  8. Đorđević N, Novaković T, Dolićanin Z, Jakovljević V, Veljković B. The effects of maternal thrombophilia on the redox homeostasis of amniotic fluid and amniotic fluid cells. IV symposium – SBERS2020. November 12–14, 2020. Abstract Book p. 65.
  9. Đorđević N, Dolićanin Z. Oxidative stress modulation is involved in anticancer activity of estradiol. 2nd International Symposium on Multidisciplinary Studies (ISMS), Rome, Italy. May 18–21, 2017. Abstract Book, p. 90.
  10. Djordjevic NZ, Babic GM, Milosevic JM, Dolicanin ZC, Markovic SD. Estradiol-possible therapy in preeclampsia. 1st ISMS, Belgrade, Serbia. October 20–23, 2016. Abstract Book p. 46.
  11. Drekovic NE, Lekovic MH, Granica NDz, Dolicanin ZC, Djordjevic NZ. Control of colorectal carcinoma proliferative capacity through inhibition of nitric oxide. 1st ISMS, Belgrade, Serbia. October 20–23, 2016. Abstract Book p. 47.
  12. Granica NDz, Lekovic MH, Drekovic NE, Dolicanin ZC, Djordjevic NZ. Proliferative capacity of colorectal carcinoma cells in hypoxia. 1st ISMS, Belgrade, Serbia. October 20–23, 2016. Abstract Book p. 48.
  13. Novakovic T, Dolicanin Z, Babic G, Djordjevic N. A correlation between hematological changes and fetal cells micronuclei in pregnant women with hypothyroidism. RAD4, Nis, Serbia. May 23–27, 2016. Abstract Book p. 37.