Laboratorija za bioneorgansku hemiju

Naučnoistraživačka delatnost fokusira se na razvoj novih jedinjenja prelaznih jona metala sa potencijalnom antitumorskom aktivnošću. Istražuje se stabilnost ovih kompleksa i njihova interakcija sa biomolekulima. Laboratorija takođe razvija inovativne terapije, kao što su gelovi na bazi prirodnih biljaka, i uključena je u istraživanja primene netoksičnih lekova u kliničkim uslovima. Koriste se napredne tehnologije, kao što su PET i CT, kako bi se procenili efekti terapija i pratila njihova interakcija sa ljudskim organizmom.

Misija Laboratorije za bioneorgansku hemiju je da kroz inovacije i napredna istraživanja doprinese razvoju novih terapija i lekova, posebno u oblasti antikancerogenih tretmana.

Vizija Laboratorije za bioneorganska istraživanja je da se razvije u Centar izvrsnosti u oblasti interdisciplinarnih i transdisciplinarnih istraživanja i doprinese integraciji Državnog univerziteta u Novom Pazaru u međunarodni naučnoistraživački prostor.

Laboratorija za bioneorgansku hemiju 1
Laboratorija za bioneorgansku hemiju 2
Laboratorija za bioneorgansku hemiju 3

Naučnoistraživački tim

Prof. dr Tanja Soldatović
Prof. dr Tanja Soldatović
glavni istraživač
tsoldatovic@np.ac.rs
Doc. dr Dušica Popović
Doc. dr Dušica Popović
dusicapopovic@np.ac.rs
Majda Kolenović Serezlić
Majda Kolenović Serezlić
asistent
mkolenovic@np.ac.rs
Elma Šaćirović
Elma Šaćirović
saradnik u nastavi
esacirovic@np.ac.rs

Istraživačka oprema

  • UV-Vis spektrofotometar sa pratećom opremom

Projekti u okviru kojih se realizuju istraživanja

Domaći projekti

Republika Srbija, Autonomna pokrajina Vojvodina, Pokrajinski sekretarijat za visoko obrazovanje i naučnoistraživačku delatnost, projekat od značaja za razvoj naučnoistraživačke delatnosti AP Vojvodine za projektni ciklus 2021–2025. godine: „Eksperimentalno klinička procena efekta antikancerske terapije modulacijom NPL4 / NF-kB / HIF-1a / VEGF, ROS ili folatne signalizacije netoksičnim lekovima i 18F FDG pozitronskom emisionom tomografijom / kompjuterizovanom tomografijom", rukovodilac prof. dr Jasna Mihailović (broj 142-451-2676/2021)

Međunarodni projekti

Međunarodni naučni projekat Federalnog ministarstva obrazovanja i nauke Federacije Bosne i Hercegovine (2025) „Razvoj kompleksa vanadija kao antidijabetskih agenasa", nosilac projekta Prirodno-matematički fakultet, Univerzitet u Sarajevu, BIH, rukovodilac prof. dr Adnan Zahirović

Saradnja sa drugim naučnoistraživačkim institucijama

Institucije u zemlji

  • Hemijski fakultet Univerziteta u Beogradu
  • Prirodno-matematički fakultet Univerziteta u Kragujevcu
  • Fakultet medicinskih nauka Univerziteta u Kragujevcu
  • Medicinski fakultet Univerziteta u Novom Sadu
  • Institut za radiologiju i onkologiju Srbije
  • Institut za informacione tehnologije Univerziteta u Kragujevcu

Institucije iz inostranstva

  • Nemačka — Inorganic Chemistry i Computer Chemistry Center, University of Erlangen-Nürnberg
  • Poljska — Faculty of Chemistry, Nicolaus Copernicus University in Toruń
  • Rusija — Faculty of Physics, St. Petersburg State University
  • Jordan — Al-Huson University College, Al-Balqa Applied University, Irbid
  • Egipat — Department of Chemistry, University of Cairo
  • Turska — Mehmet Akif University, Burdur
  • Hrvatska — Faculty of Pharmacy and Biochemistry, University of Zagreb; Ruđer Bošković Institute
  • Italija — Department of Chemistry, University of Sassari
  • Bosna i Hercegovina — Faculty of Science, University of Sarajevo

Postignuti rezultati

Master radovi

Odabrani naučni radovi

  1. Popović DJ, Popović KJ, Miljković D, Popović JK, Lalošević D, Poša M, Dolićanin Z, Čapo I. Diclofenac and metformin synergistic dose dependent inhibition of hamster fibrosarcoma, rescued with mebendazole. Biomed. Pharmacother. 2023;167:115528. DOI ISSN: 0753-3322 M21a
  2. Popović KJ, Popović DJ, Miljković D, Popović JK, Lalošević D, Čapo I. Co-treatment with nitroglycerin and metformin exhibits physicochemically and pathohistologically detectable anticancer effects on fibrosarcoma in hamsters. Biomed. Pharmacother. 2020;130:110510. DOI ISSN: 0753-3322 M21a
  3. Popović KJ, Popović DJ, Miljković D, Popović JK, Lalošević D, Poša M, Čapo I. Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma. Biomed. Pharmacother. 2021;143:112168. DOI ISSN: 0753-3322 M21a
  4. Soldatović TV, Selimović E, Milivojević N, Jovanović M, Šmit B. Novel heteronuclear Pt(II)‐L‐Zn(II) complexes: synthesis, interactions with biomolecules, cytotoxic properties. Appl Organomet Chem. 2020;34(10):e6023. DOI ISSN: 0268-2605 M21
  5. Soldatović TV, Šmit B, Mrkalić EM, Matić SLj, Jelić RM, Ćendić Serafinović M, Gligorijević N, Čavić M, Aranđelović S, Grgurić-Šipka S. Exploring heterometallic bridged Pt(II)-Zn(II) complexes as potential antitumor agents. J. Inorg Biochem. 2023;240:112100–112122. DOI ISSN: 0162-0134 M21
  6. Kolenović Serezlić M, Hasić R, Ašanin D, Šmit B, Matić SLj, Ćendić Serafinović M, Nikodijević D, Jovankić J, Grgurić-Šipka S, Soldatović TV. Heterometallic bridged Pt(II)-Zn(II) complexes: influence of the substituent in 4′-position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules. Appl Organomet Chem. 2024;38(4):e7413. DOI ISSN: 0268-2605 M21
  7. Vučelj S, Hasić R, Ašanin DP, Šmit B, Caković A, Bogojeski J, Ćendić Serafinović M, Simović Marković B, Stojanović B, Pavlović S, Stanisavljević I, Ćorović I, Dimitrijević Stojanović M, Jovanović I, Soldatović TV, Stojanović B. Modes of interactions with DNA/HSA biomolecules and comparative cytotoxic studies of newly synthesized mononuclear zinc(II) and heteronuclear platinum(II)/zinc(II) complexes toward colorectal cancer cells. Int. J. Mol. Sci. 2024;25:3027, 1–27. DOI ISSN: 1422-0067 M21
  8. Redžepović I., Soldatović TV. Comparative cheminformatics study on structural and physiological similarity of bridged heterometallic complexes. MATCH Commun. Math. Comput. Chem. 2024;92:317–336. DOI ISSN: 0340-6253 M21
  9. Jörg J, Puchta R, Soldatović T, Kolenović Serezlić M, van Eldik R. The ion selectivity of the Goedken-Peng Cryptand: Prediction of ion selectivity by quantum chemical calculations XVII§. J. Coord. Chem. 2024;77(11):1256–1265. DOI M22
  10. Safiye T, Mahmutović E, Biševac E, Zimonjić V, Dubljanin D, Kovačević A, Nenezić N, Radlović A, Salihagić Z, Ajdinović A, Minić S, Šaćirović E, Uzelac J, Dolićanin Z, Dubljanin J. Factors associated with burnout syndrome in Serbian healthcare workers during the COVID-19 Pandemic. Healthcare. 2025;13(2):106, 1–19. DOI ISSN: 2227-9032 M22
  11. Popović DJ, Popović KJ, Lalošević D, Popović JK. Effects of metformin and its combinations with other repurposed drugs on fibrosarcoma in hamsters. Srp. Arh. Celok. Lek. 2024;152(3-4):130–137. DOI ISSN: 0370-8179 M23
  12. Popović KJ, Popović DJ, Lalošević D, Popović JK. Experimental evaluation of the effects of anticancer modulation therapy on MAPK/PI3K/AKT/mTOR/NF-κB signaling with non-toxic drugs. Srp. Arh. Celok. Lek. 2024;152(3-4):138–146. DOI ISSN: 0370-8179 M23
  13. Popović JK, Popović DJ, Popović KJ, Miljković D, Lalošević D, Dolićanin Z, Čapo I. Immunohistochemical evidences of anticancer actions of metformin with other repurposed drug combinations and correlation with hamster fibrosarcoma tumor size. J. Serb. Chem. Soc. 2024;89(5):643–656. DOI ISSN: 0352-5139 M23

Saopštenja na naučnim skupovima

  1. Soldatović T. Novel perspective of anticancer metal-based drugs: Characteristics of heterometalic complexes and their potential applications. 7th Int. Electron. Conf. Med. Chem., 1–30 November 2021. DOI M31
  2. Soldatović T. A new approach to the design of metal-based antineoplastic drugs. 6th Congress of SDIR, 2–4 October 2023, Belgrade. Oncology Insights, No.1, 2023, L03, p. 27. M31
  3. Soldatović T. Application of the hard-soft acid base theory on prediction of bionorganic substitution reactions. ERASMUS International Academic Research Symposium, 5–6 April 2019, Izmir, Turkey. Book of Abstracts, P18. M32
  4. Kolenović Serezlić M, Matić SLj, Šmit B, Soldatović TV. In vitro antigenotoxicity of novel heterometallic dinuclear complexes. 8th Int. Electron. Conf. Med. Chem., 1–30 November 2023. DOI M33
  5. Eminović V, Papić Dž, Kolenović-Serezlić M, Hasić R, Soldatović T. Novel heterometallic type cis-Pt(II)-L-Zn(terpy-X) complexes with potential anti-tumor activity. 9th International Hippocrates Congress, 9–10 October 2022. Book of Abstracts, P29. M34
  6. Popović KJ, Popović DJ, Dolićanin Z, Popović JK. Convolutional integrals, spline polynomials and fractional order derivatives in more accurate pharmacokinetic, bioequivalence and individual anticancer dosage evaluations. RAD 2024, June 17–21, Herceg Novi, Montenegro. Book of Abstracts, p. 148. M34
  7. Kolenović Serezlić M, Soldatović T, Grgurić Šipka S. Heterometallic bridged Pt(II)-Zn(II) complexes. 5th ICCCEB&H 2024, 27–30 June, Sarajevo. Book of Abstracts, PP-IC-04, P111. M34
  8. Popović KJ et al. ROS and NF-B role in repurposed drugs treatment of hamster fibrosarcoma. Serbian Biochemical Society Twelfth Conference, 21–23.09.2023, Belgrade. Proceedings, p. 79. M34
  9. Popović DJ et al. Anticancer effects of non-toxic repurposed drugs on hamster fibrosarcoma. 6th Congress of SDIR, October 2–4, 2023, Belgrade. Oncology Insights, 2023;1(1):94–95 (P38). M34
  10. Popović KJ et al. Stimulation and inhibition of NF-B by repurposed drugs — effects on hamster fibrosarcoma. 6th Congress of SDIR, October 2–4, 2023, Belgrade. Oncology Insights, 2023;1(1):101 (P46). M34
  11. Kolenović Serezlić M, Nikolić S, Soldatović T, Grgurić Šipka S. Novel Pt(II) complexes with Schiff-base ligands: synthesis and characterization. 8th Conference of Young Chemists of Serbia, October 29, 2022, Belgrade. Book of Abstracts, p. 82. M64
  12. Jorg J, Puchta R, Soldatović TV, Kolenović Serezlić M, van Eldik R. The ion selectivity of the Goedken-Peng cryptand. 10th Conference of Young Chemists of Serbia, October 26, 2024, Belgrade. Book of Abstracts SCFM PP 05, p. 170. M64
  13. Popović DJ et al. Effects of metformin and its combinations with other repurposed drugs on fibrosarcoma in hamsters. 1st Forum of the Academy of Medical Sciences of SMS. Srp Arh Celok Lek. 2023;151(1-2):132–133. M64
  14. Popović KJ et al. Experimental evaluation of the effects of anticancer modulation therapy on MAPK/PI3K/AKT/mTOR/NF-kB signaling with non-toxic drugs. 1st Forum of the Academy of Medical Sciences of SMS. Srp Arh Celok Lek. 2023;151(1-2):133. M64

Monografije

  1. Soldatović TV. Application of The Principle of Hard and Soft Acids and Bases to Mechanisms of Bioinorganic Reactions. Livre de Lyon Publisher, Lyon, France, 2019. ISBN: 978-2-490773-02-2 M12
  2. Soldatović T. Uticaj supstitucionih reakcija kompleksa platine(II) sa biomolekulima na njihovu citotoksičnost. Matica srpska, Novi Sad, 2014. ISBN: 978-86-7946-125-4 M41
  3. Popović J, Nikolić B, Popović K, Milošević N, Popović D. Statistički principi u kliničkoj farmaciji. Medicinski fakultet, Novi Sad, 2021. ISBN: 978-86-7197-649-7 M42