Laboratorija za bioorgansku hemiju

Naučnoistraživačka delatnost Laboratorije za bioorgansku hemiju obuhvata interdisciplinarna istraživanja iz nekoliko međusobno povezanih oblasti – organske hemije, biohemije, medicinske hemije, fitohemije, farmakognozije, farmakologije i ekologije. Osnovni pravci istraživanja oslanjaju se na savremena saznanja i primenu savremenih metoda u cilju razumevanja i rešavanja kurentnih problema iz oblasti hemije, biologije i medicine. Nova saznanja o bioaktivnim molekulima iz prirodnih izvora, derivatima i strukturnim analozima prirodnih proizvoda, kao i mehanizmu njihovog delovanja, osnovni su preduslov za njihovu upotrebu u primenjenim naukama i oblastima, kao što su medicina, farmacija, poljoprivreda itd.

Misija Kroz naučnoistraživački rad i edukaciju, uz permanentno usavršavanje istraživača i istraživanja, doprineti unapređenju postojećih i razvoju novih saznanja u oblasti organske hemije, biohemije, medicinske hemije, fitohemije, farmakognozije, farmakologije i ekologije.

Vizija Postati prepoznatljiv u domaćoj i međunarodnoj akademskoj, stručnoj, i široj javnosti, i time doprineti integraciji Državnog univerziteta u Novom Pazaru u evropski naučnoistraživački prostor.

Naučnoistraživački tim

Dr Milan Dekić
Dr Milan Dekić
vanredni profesor, glavni istraživač
mdekic@np.ac.rs
Dr Marko Mladenović
Dr Marko Mladenović
docent i viši naučni saradnik
mmladenovic@np.ac.rs
Dr Vesna Zeljković
Dr Vesna Zeljković
docent
vzeljkovic@np.ac.rs
Samira Plojović
Samira Plojović
asistent
saplojovic@np.ac.rs

Pridruženi članovi

Studenti master i doktorskih studija koji tokom svake školske godine u Laboratoriji realizuju eksperimentalna istraživanja za potrebe izrade završnih radova.

ISTRAŽIVAČKI RESURSI

Istraživačka oprema

  • GC/MS sistem Agilent 7890B/240-MS
  • Vakuum-uparivač sa membranskom vakuum-pumpom Büchi Rotavapor R-210
  • Inkubator/sterilizator
  • Vodeno kupatilo
  • Magnetne mešalice sa grejačem
  • Kalota 5000 ml
  • Aparatura i oprema za analitičku i preparativnu TLC
  • UV lampa
  • Laboratorijski rešo
  • Ultrazvučna kada
  • Analitička vaga
  • Tehnička vaga

Projekti u okviru kojih se realizuju istraživanja

  • Projekat Ministarstva za nauku, tehnološki razvoj i inovacije (MNTRI) br. 451-03-65/2024-03/200252
  • Projekat iz programa „Dijaspora 2024" pod nazivom „From waste to resource: Exploring the bioactive potential of fermented ginger syrup production residues through chemical profiling and evaluation of antimicrobial, antioxidant, and anti-inflammatory activities (G-RENEW)", reg. br. 219, Fond za nauku Republike Srbije

Saradnja sa drugim naučnoistraživačkim institucijama

  • Laboratorija za organsku hemiju i biohemiju, Prirodno-matematički fakultet u Nišu
  • Institut za informacione tehnologije Univerziteta u Kragujevcu
  • Katedra za farmaceutsku hemiju, Farmaceutski fakultet u Beogradu
  • Institut de Chimie de Nice, UMR 7272, Université Côte d'Azur, Nice, France
  • School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland
  • Department of Biological Sciences and Health, Federal University of Amapá, Macapá, Brazil
  • Hochschule Anhalt University of Applied Sciences, Köthen, Germany

POSTIGNUTI REZULTATI

Odabrani naučni radovi

  1. Dekić MS, Plojović SA, Gusinac AM, Selimović ES, Radulović NS. Comprehensive mass spectral libraries and gas chromatographic data for esters of regioisomeric furanmethanols: addressing identification challenges in food chemistry. Food Res. Int. 2025;209:116294. SCI IF 7.0, M21a. DOI
  2. Dimitrijević MŽ, Mladenović MZ, Nešić MD, Dekić MS, Raičević VN, Radulović NS. New Oxygenated Methoxy-p-Cymene Derivatives from Leopard's Bane (Doronicum columnae Ten., Asteraceae) Essential Oil. Molecules 2025;30:302. SCI IF 4.2, M21. DOI
  3. Dekić M, Gusinac A, Jeremić S, Jakovljević V, Plojović S, Jovanović D, Radulović N. Abietane diterpenoid salvipisone: structure elucidation, conformational analysis, and antimicrobial activity. J. Mol. Struct. 2025;1321(1):139807. SCI IF 4.0, M22. DOI
  4. Jovanović DZ, Nešić MS, Dekić MS, Ristić NR, Radulović NS. Resolving unresolvable multiplets: ¹H NMR spectral simulation of selected sesquiterpenoids from the acorenone-rich rhizome essential oil of sweet flag, Acorus calamus L. J. Mol. Struct. 2025;1321(5):140205. SCI IF 4.0, M22. DOI
  5. Simijonović D, Avdović E, Jovičić Milić S, Antonijević M, Milenković D, Marković K, Grujović M, Stojković DLj, Dekić M, Marković M. Investigation of Antimicrobial and Anti-Inflammatory Efficacy of Newly Synthesized Pyrogallol-Coumarin Hybrids: In Vitro and In Silico Studies. Pharmaceutics 2024;16(11):1472. SCI IF 5.4, M21. DOI
  6. Radulović NS, Mladenović MZ, Lima CS, Müller ECA, Moraes da Costa EV, Martins RV, Boylan F. Amazon Rainforest Hidden Volatiles—Part I: Unveiling New Compounds from Acmella oleracea (L.) R.K. Jansen Essential Oil. Plants 2024;13:1690. SCI IF 4.0, M21. DOI
  7. Mladenović MZ, Huang O, Wang B, Ginestet A, Desbiaux D, Baldovini N. Chemical investigation on the volatile part of the CO₂ supercritical fluid extract of infected Aquilaria sinensis (Chinese Agarwood). Molecules 2024;29:2297. SCI IF 4.2, M21. DOI
  8. Stojanović NM, Mladenović MZ, Ranđelović PJ, Radulović NS. The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent – is the citronellal the activity carrier? J. Ethnopharmacol. 2023;314:116661. SCI IF 4.8, M21a. DOI
  9. Raičević V, Mladenović M, Aćimović M, Radulović N. New Esters from the Essential Oil of Dry Flowers of Elder (Sambucus nigra L.). J. Sci. Food Agric. 2023;104:1308. SCI IF 3.3, M21. DOI
  10. Radulović NS, Mladenović MZ, Dekić MS, Boylan F. Synthesis of small libraries of natural products. Part II: identification of a new natural product from the essential oil of Pleurospermum austriacum (L.) Hoffm. (Apiaceae). Molecules 2023;28:4574. SCI IF 4.2, M21. DOI
  11. Mladenović MZ, Ristić MN, Bogdanović AI, Ristić NR, Boylan F, Radulović NS. Wax composition of Serbian Dianthus spp. (Caryophyllaceae): identification of new metabolites and chemotaxonomic implications. Plants 2023;12:2094. SCI IF 4.0, M21. DOI
  12. Radulović NS, Mladenović MZ, Vukićević DR, Stojanović NM, Ranđelović PJ, Stojanović-Radić ZZ, Boylan F. Pulicaria dysenterica (L.) Bernh. – Rightfully Earned Name? Identification and Biological Activity of New 3-Methoxycuminyl Esters from P. dysenterica Essential Oil. Plants 2022;11:3340. SCI IF 4.5, M21. DOI
  13. Stojanović NM, Mladenović MZ, Maslovarić A, Stojiljković NI, Ranđelović PJ, Radulović NS. Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies. J. Ethnopharmacol. 2022;284:114788. SCI IF 5.4, M21a. DOI
  14. Dekić M, Radulović N, Dekić D, Ličina B. The essential oil of the condiment species Clinopodium thymifolium (Scop.) Kuntze: new natural products and seasonal variation. J. Sci. Food Agric. 2022;102(6):2437–2444. SCI IF 4.125, M21. DOI
  15. Radulović NS, Nikolić MG, Mladenović MZ, Ranđelović P, Stojanović NM, Stojanović-Radić Z, Jovanović Lj. Antispasmodic and antimicrobial activities of pyrazole-containing ferrocenyl alkanols vs. their phenyl analogs. Appl. Organomet. Chem. 2022;36:e6514. SCI IF 4.072, M21. DOI
  16. Genčić MS, Stojanović NM, Mladenović MZ, Radulović NS. An HPLC-based assay for improved measurement of glutamate decarboxylase inhibition/activation. Neurochem. Int. 2022;161:105433. SCI IF 4.2, M22. DOI
  17. Genčić MS, Aksić JM, Živković Stošić MZ, Đorđević MR, Mladenović MZ, Radulović NS. New neryl esters from Helichrysum italicum (Roth) G. Don (Asteraceae) essential oil. Nat. Prod. Res. 2022;36:2002–2008. SCI IF 2.2, M22. DOI